First of all “people are always afraid of what they don't understand“. So negative sentiment and confusion are usually intertwined. In all cases there is some confusion.
However:
Toward negative sentiment (the mind is closed):
How could you ...
How could anyone ...
Why anyone would ...
How does anyone ...
Toward request for information (the mind is open):
How could one ...
How can I ...
How do I ...
How does one ...